The AfterMath of ANE

 What is the definition of comorbidity? 
Comorbidity is the presence of one or more additional diseases or disorders co-occurring with (that is, concomitant or concurrent with) a primary disease or disorder; in the countable sense of the term, a comorbidity (plural comorbidities) is each additional disorder or disease. The additional disorder may be a behavioral or mental disorder.
Timeline for ANE (including trigger and post ANE acute phase)
Initial Illness:
Influenza A,  Influenza C and Influenza B, Novel Influenza A (H1N1), Parainfluenza, Varicella, Human Herpesvirus 6 and Herpesvirus 7
(HHV-6 and HHV-7), Enterovirus, Novel Reovirus train (MRV2Tou05), Rotavirus, Herpes Simplex virus, Rubella, Coxsackie A9, bacterial & viral colds and Measles, among which the Influenza virus and HHV-6 are most common.
The Disease by it’s many names:
acute necrotizing encephalopathy of childhood (ANEC ) usually used for non genetic
acute necrotizing encephalopathy usually refered to for the genetic cases
ANE1  used to be used for genetic cases.
acute necrotizing encephalitis – this term is still used however incorrect encephalitis refers to an illness and not a disease.
ADANE ( autosomal dominant acute necrotizing encephalopathy)
IIAE3 (  Infection-induced acute encephalopathy 3)
postinfectious acute necrotizing hemorrhagic encephalopathy
susceptibility to acute necrotizing encephalopathy
susceptibility to infection-induced acute encephalopathy
susceptibility to infection-induced acute encephalopathy 3
Alternative diagnosis before MRI is confirmed:
Viral encephalitis
Mitochondrial disorder
ADEM (acute dessiminating encephalomyelitis)
Juvenile multiple sclerosis
Guillian Barre Syndrome
Symptoms at onset of disease:
Respiratory Distress
Loss of consciousness
Loss of balance
Repeated vomiting
Double vision
Extreme Lethargy
The AfterMath (Ie:after the acute stage):
Traumatic Brain Injury
Cerebal Palsy
Increase Muscle tone
Decrease Muscle tone
Loss of speak
Parkinsonian Symptoms
Suicidal Ideation
Chronic/frequent headaches
Sensitivity to light
Sensitivity to sound
Sensitivity with overstimulation
Problems with speech
Loss of emotional regulation
Memory problems
Concentration problems
Difficulty with changes in routine
Emotional breakdowns.
Difficulty regulating behaviors and emotions, which may result in temper tantrums,   anxiety, and aggression
Perseveration of some special event they are looking forward to or subject they love.
Urinary incontinence
Fecal incontinence
Insomnia/sleep disturbance
Gastric motility issues
Families are often left trying to figure out just how to navigate the world with their new child and it takes years to fully understand your child’s new abilities and limitations.
ANE is a devastating disease for most family leaving not only the individual marked for life but leaving entire families marked and in need of incredible support.  It is important to support research and support families through shared knowledge to help them guide through the next steps.

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